Safety profiles were similar between the AYA and older groups, but exposure to antitumor drugs of the VAC tended to be lower in the older group; median number of total cycle of the VAC was 13 in AYA and 10 in older, cumulative cyclophosphamide dose was 16.8 g/m2 in AYA and 12.8 g/m2 in older, and number of vincristine skips was six in AYA and 12 in older, respectively. Aim: Pathology records were searched for adults (age, >18) with rhabdomyosarcoma treated at our musculoskeletal tumor center. Also called VAC. Lancet Oncol. Multidrug resistance proteins in rhabdomyosarcomas: comparison between children and adults. DeVita VT, Jr, Lawrence TS, Rosenberg SA. 2018 Sep 20;36(27):2770-2777. doi: 10.1200/JCO.2018.77.9694. It is not yet known which combination chemotherapy regimen is more effective when given together with radiation therapy in treating patients with rhabdomyosarcoma. Edited by VAC chemotherapy in children and adolescents with soft- Banzet P, Holland JF, Khavat D, Weil M. Vinorelbine and continuous low-dose cyclophosphamide as maintenance chemotherapy in patients with high-risk rhabdomyosarcoma (RMS 2005): a multicentre, open-label, randomised, phase 3 trial. On the basis of patients receiving standard therapy and IE, compared with these results, Koscielniak et al. 2012 Sep;70(3):391-7. doi: 10.1007/s00280-012-1920-0. Rhabdomyosarcoma is an exceedingly rare tumor in adults, and standard chemotherapy used for children is much less effective in adults. Komdeur R, Klunder J, van der Graaf WT, et al. There were no differences in the response rate of the VAC between AYA (64.3%) and older (66.7%), either. Your child’s healthcare team will consider your child’s needs to plan the drugs, doses and schedules of chemotherapy. Alveolar rhabdomyosarcoma of the vulva in an adult: a case report and literature review. Chemotherapy is usually effective for rhabdomyosarcoma and should be seen as the keystone of its treatment, while non-rhabdomyosarcoma soft-tissue sarcomas … COVID-19 is an emerging, rapidly evolving situation. PURPOSE: The study goal was to improve outcome in children with rhabdomyosarcoma by comparing risk-based regimens of surgery, radiotherapy (RT) and chemotherapy. Efficacy of topotecan and cyclophosphamide given in a phase II window trial in children with newly diagnosed metastatic rhabdomyosarcoma: a Children's Oncology Group study. With the appropriate dose modification, the VAC regimen could be a feasible treatment option for RMS patients >40 years old. Epub 2019 Sep 24. link to original article PubMed; VI, then VDC/IE, then VAC, then VI Outcome of 449 adult patients with rhabdomyosarcoma: an observational ambispective nationwide study. There was no si… The results were published onlineahead of print in the Journal of Clinical Oncology. 2018;7(8):4023-4035. With the median follow‐up of 89.4 weeks (range 17.7–263.1 weeks), the median progression‐free survival (PFS) and overall survival (OS) of the VAC regimen were 61.4 weeks (95% CI, 32.6–90.3) and 104.0 weeks (95% CI, 43.8–164.2), respectively, with no significant differences in the PFS or OS between the AYA and older patients. The question is raised that vincristine, d-actinomycin, and cyclophosphamide (VAC) chemotherapy may not be administered as per schedule for adult RMS; consequently, low dose intensity (DI) leads to poor prognosis. Curr Oncol Rep. 2003 Nov;5(6):505-9. doi: 10.1007/s11912-003-0012-z. Nihon Geka Gakkai Zasshi.  |  PATIENTS AND METHODS: Eight hundred eighty-three previously untreated eligible patients with nonmetastatic rhabdomyosarcoma entered the Intergroup Rhabdomyosarcoma Study-IV (IRS-IV) (1991 to 1997) after surgery and were … All patients with rhabdomyosarcoma require multiagent chemotherapy. Epub 2018 Aug 9. 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